New York Gov. Andrew M. Cuomo unveiled an election-year grab bag of policy proposals Wednesday in his fourth State of the State, including funding for a genome research consortium between Buffalo and Manhattan.

Cuomo said he will dip again into his pledge made several years ago to spend $1 billion on Buffalo job creation efforts by authorizing a $100 million genome research program -- with $50 million going to the University at Buffalo and potentially other groups in the Buffalo area -- to connect scientists in Western New York with genome researchers at a new center in Manhattan.

Cuomo and researchers involved in the project said jobs and scientific breakthroughs to treat cancer and other diseases will result from the state investment. He said five companies already have committed to locate or expand on the Buffalo Niagara Medical Campus to be a part of a consortium with a not-for-profit genome center in Manhattan that opened last fall. Cuomo said the research work "will create an entirely new industry for Western New York."

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Audience members included Buffalo Mayor Byron W. Brown, who praised the genome research project. "It's another huge investment in our community," he said.

Robert J. McCarthy contributed to this report.