This is perhaps not an exhaustive list, but there are plenty of organizations to pick from. Make 2009 a year that you decide to donate from your personal finances--if you are not already doing so.
I personally donate to serveral national and local charities. Hard to believe, but World Vision's headquarters is only about 10 miles from where I live.
RELIEF, CHARITABLE & OUTREACH ORGANIZATIONS
Action Against Hunger: www.aah-usa.org
ADRA International: www.adra.org
Africa Leadership Mocha Club: www.africanleadership.org
Air Serv International: www.airserv.org
American Friends Service Committee: www.afsc.org
American Jewish Joint Distribution Committee, Inc: www.jdc.org
American Jewish World Service: www.ajws.org
American Red Cross: www.redcross.org
AmeriCares: www.americares.org
America's Second Harvest: www.secondharvest.org
Ananda Marga Universal Relief Team (AMURT): www.amurt.net
ARMDI, Israeli Red Cross: www.armdi.org
Association for India's Development: www.aidindia.org
B'nai B'rith International: www.bnaibrith.org
Baptist World Aid: www.bwanet.org/bwaid
Big Brothers Big Sisters: www.bbbsi.org and www.bbbsa.org
Brother's Brother Foundation: www.brothersbrother.org
CARE: www.care.org
Catholic Charities USA: www.catholiccharitiesusa.org
Catholic Relief Services: www.catholicrelief.org
Christian Children's Fund: www.christianchildrensfund.org
Christian Disaster Response: www.cdresponse.org
Christian Reformed World Relief Committee: www.crwrc.org
Church World Service: www.churchworldservice.org
Concern Worldwide: www.concernusa.org
Convoy of Hope: www.convoyofhope.org
Corporation for National and Community Service Disaster Relief Fund: www.nationalservice.gov
Dave Thomas Foundation for Adoption: www.davethomasfoundationforadoption.org
Direct Relief International: www.directrelief.org
Disaster Psychiatry Outreach: www.disasterpsych.org
Doctors Without Borders: www.doctorswithoutborders.org
Episcopal Relief and Development: www.er-d.org
Food for the Hungry, Inc.: www.fh.org
Feed the Children: www.feedthechildren.org
Habitat for Humanity International: www.habitat.org
Heart to Heart International: www.hearttoheart.org
Humane Society of the United States: www.hsus.org
International Aid: www.internationalaid.org
International Federation of Red Cross and Red Crescent Societies: www.ifrc.org
International Medical Corps: www.imcworldwide.org
International Orthodox Christian Charities: www.iocc.org
International Relief Teams: www.IRTeams.org
International Rescue Committee: www.theIRC.org
Islamic Relief Worldwide: www.islamic-relief.com
Kick Start: http://kickstart.org/
Latter-Day Saint Charities: www.lds.org/ldsfoundation
Lutheran World Relief: www.lwr.org
MAP International: www.map.org
Mennonite Disaster Service: www.mds.mennonite.net
Mercy Corps: www.mercycorps.org
Nazarene Disaster Response: www.nazarenedisasterresponse.org
National Mentoring Partnership: www.mentoring.org
Network for Good: www.networkforgood.org
Northwest Medical Teams: www.nwmedicalteams.org
Operation Blessing International: www.ob.org
Operation USA: www.opusa.org
Oxfam America: www.oxfamamerica.org
Oxfam International: www.oxfam.org
Plan USA: www.planusa.org
Presbyterian Disaster Assistance: www.pcusa.org
Prison Fellowship International: www.pfm.org
Project Concern International: www.projectconcern.org
Project HOPE: www.projecthope.org
Relief International: www.ri.org
Salvation Army: www.salvationarmy.org
Save the Children USA: www.savethechildren.org
Share Our Strength: www.strength.org
Stop Hunger Now: www.stophungernow.org
U.N. World Food Programme: www.wfp.org
UMCOR: www.umcor.org
UNICEF: www.unicef.org
USAID: www.usaid.gov
Water Missions International: www.watermissions.org
World Concern: www.worldconcern.org
World Emergency Relief: www.worldemergencyrelief.org
World Hope International: www.worldhope.org
World Relief: www.worldrelief.org
World Vision: www.worldvision.org