Some prominent departures have included Oxiris Barbot, who resigned as New York City’s health commissioner to protest Democratic Mayor Bill de Blasio’s handling of the crisis, while Cathy Slemp, commissioner of the West Virginia Department of Health and Human Resources, vacated her role at the behest of Gov. Jim Justice (R), who complained about the accuracy of the state’s numbers. Even California's health officer has resigned.
Besides the conflict in, I expect, strategy and communications, there have been plenty of local health officers who have had the public come after them personally. Threatening them and their families physically. Those types of pressures have caused local health officials to call it quits. Some thinking I suppose, "I didn't sign up for this!"
In all the pandemic planning I've done, the personal threat to health officers doing their duty never came up.